Carlisle High School is a public high school located in Carlisle, Pennsylvania, United States.

It serves grades 9–12 for the Carlisle Area School District.

The district includes Carlisle and Mount Holly Springs boroughs (the latter being an exclave of the school district), and the townships of and Dickinson and North Middleton.

The district also includes the Carlisle Barracks census-designated place as well as most of the Schlusser census-designated place.

[2] The demographic breakdown of the 1,526 students enrolled for 2018–19 was: 27.7% of the students were eligible for free or reduced-cost lunch.