Carlo Francesco Cesarini, (c.1666 – after 2 September 1741) was an Italian composer born in San Martino al Cimino near Viterbo and active in Rome from 1690.
Cesarini also served as the maestro di cappella in the Chiesa del Gesù from 1704 until 31 August 1741.
The opera Clearco in Negroponte which he composed with Giovanni Lorenzo Lulier and Tommaso Bernardo Gaffi inaugurated the public opening of the Teatro Capranica on 18 January 1695.
He also set to music many oratorios on Benedetto Pamphilj's texts: San Vincislao (1704), Il figliol prodigo (1707), Oratorio per l'Assunzione della beatissima Vergine (1713), e Il trionfo del Tempo nella Bellezza ravveduta (1725).
The last known records of him date from early September 1741 and document his retirement as the maestro di cappella of the Chiesa del Gesù due to ill health.