[3][4] Carlo's father was the last ruling despot of Epirus, losing his last lands in Greece in 1479 to conquest by the Ottoman Empire.
[8][9] On 29 February 1480, Leonardo, his brothers and Carlo arrived in Rome,[6] seeking money from Pope Sixtus IV.
[6] After Leonardo's death at some point in the pontificate of Pope Alexander VI (r. 1492–1503),[1][10] Carlo continued to live in Rome, and served there as captain of the Sacred College.
[1][10] The generosity of Naples was not as great as it could have been, given that Ferdinand I, who had promised Leonardo that he would treat Carlo as his own son,[1] had been deposed by King Charles VIII of France, who thereafter took control of the Neapolitan kingdom.
[2] Carlo's claims were continued by his and Andronica's only child, the son Leonardo IV Tocco, born at some point in the 1510s.