Andreas's father had returned from exile under the protection of the Papacy to Constantinople in 1476 and had been generously provided for by Mehmed II of the Ottoman Empire, who had conquered the city from Manuel's relatives in 1453.
[3][4] Previously, Manuel had lived with his brother Andreas under the protection of the papacy in Rome, but a constant cutting of their provided pension had led to a poor financial situation.
[5] In 1932, Andreas was identified by Greek Byzantinist Dionysios Zakythinos as the same individual as Mesih Pasha, an Ottoman soldier who partook in a failed attack on Rhodes in 1480.
[1] Though nobles with the name Palaiologos are recorded in later centuries, notably a family from Pesaro in Italy who claimed descent from the Imperial dynasty, their lineages cannot be confidently verified.
[1] If only those Palaiologoi whose legitimate male-line descent can be confidently verified are considered, the death of Andreas at some point in the 16th century marked the extinction of the imperial family.