He made considerable efforts to protect the Camposanto and its frescoes from ruin, from which it was threatened due to the destructive effects of the Napoleonic wars.
These large etchings were composed in the sharply defined "outline style", which was popular in the early nineteenth century in reaction to the soft tonal effects of 18th century stipple engravers such as Francesco Bartolozzi.
According to William Holman Hunt, study of Lasinio's book convinced the group to reject High Renaissance art in favour of these earlier works.
Lasinio's engravings also proved an important record of the frescoes, which were eventually severely damaged by bombing in World War II.
His portrayals of eminent Italians include the great explorers, Christopher Columbus and Amerigo Vespucci.