[1] Carlo Loffredo was born in Cardito, Italy on 31 March 1635 and ordained a priest in the Congregation of Clerics Regular of the Divine Providence.
[2][3] On 6 October 1670, he was appointed during the papacy of Pope Clement X as Bishop of Molfetta.
[1][2] On 19 October 1670, he was consecrated bishop by Benedetto Odescalchi, Cardinal-Priest of Sant'Onofrio, with Domenico de' Marini, Titular Archbishop of Teodosia, and Tommaso d'Aquino, Bishop of Sessa Aurunca, serving as co-consecrators.
[2] On 26 November 1691, he was appointed during the papacy of Pope Innocent XII as Archbishop of Bari-Canosa.
[2] On 10 March 1698, he was appointed during the papacy of Pope Clement XI as Archbishop of Capua.