Mannelli spent the major part of his life in Rome where he also worked during the opera performances and religious events.
As a violinist nicknamed Carlo del Violino and Carluccio di Pamfilio, he played the first violin in the most famous Roman musical ensemble of the period.
Arcangelo Corelli, who often played under Mannelli and who gradually replaced him between 1682 and 1690 as the first concertino violinist, described him as one of his most influential teachers.
Additionally, he counted him with Carlo Ambrogio Lonati and Lelio Colista among the "più valorosi professori musici di Roma", as cited in the preface of his Opus 1.
The donation was provided for members with lesser income and it ran out only towards the end of the 18th century.