Born on 21 November 1805 in Rome,[1] he was the son of the noted Roman physician Domenico Lino Morichini (1773–1837).

[2] He studied philosophy and law for seven years (1822–1818) at the University of Rome, La Sapienza, and was awarded the degree Doctor in utroque iure.

[3] In 1845 he was appointed Apostolic Nuncio to Bavaria with residence in Munich, and titular Latin archbishop of Nisibis by Pope Gregory XVI.

[5] In 1847, he was appointed Treasurer General of the Reverenda Camera Apostolica, which made him responsible for the budget of the Papal States, which was running a deficit and was relying on bank loans for current expenses.

Under the presidency of Cardinal Giacomo Antonelli, Archbishop Morichini was appointed Vice-President and Minister of Finance.

His budget was immediately wrecked by the news of the revolution in Paris in February, and the consequent withdrawal of bank financing.

[9] He was appointed bishop of Jesi, a diocese directly suffragan to the Holy See; he was allowed to retain the title of Archbishop.

The entire incident was an effort to intimidate the leaders of the papal party in the territory newly annexed by the Turin government.

On 15 July 1878, he was appointed Prefect of the Supreme Tribunal of the Signature of Justice by the new pope, Leo XIII (Pecci).

[1] Morichini was the author of: Di Giovanni Borgi mastro muratore detto Tatagiovanni e del suo ospizio per gli orfani abbandonati memoria dell'ab.