The Ospizio di San Michele a Ripa Grande (Hospice of St Michael) or Ospizio Apostolico di San Michele in Rome is a complex represented by a series of buildings in the south end of the Rione Trastevere, facing the Tiber River and extending from the bank of Ponte Sublicio for nearly 500 meters.

While large seafaring ships could not forge easily up the Tiber river to Rome; smaller boats frequently brought supplies from the coast to the city and offloaded at the Porta.

The buildings of the Ospizio di San Michele were built during the 17th and 18th centuries and served a number of purposes including an orphanage, a hospice for abandoned elderly, and jails for minors and women.

In 1679, a nephew of the new Pope Innocent XI (reigned 1676–1689), Monsignor Carlo Tommaso Odescalchi commissioned architect Mattia de Rossi to design, and within five years had built an hospice to house and train orphan children to manufacture of woven carpets and tapestries.

The smaller ancient church of Santa Maria del Buon Viaggio, on the south east end of the complex, was dedicated to sailors, who were embarking from here to travel down the Tiber.