Carlo Negrini (24 June 1826 in Piacenza – 14 March 1865 in Naples) was an Italian spinto tenor and creator of Gabriele Adorno in Verdi’s opera Simon Boccanegra.

[2] Negrini started singing in the La Scala chorus, soon making his début as a soloist in 1847 as Jacopo in Giuseppe Verdi's I due Foscari.

In 1850 Negrini sang Gastone in Gerusalemme, the Italian-language version of Giuseppe Verdi's Jérusalem, a French language remake of I Lombardi alla prima crociata , in La Scala.

Other roles he created were Adel-Muza in Giuseppe Apolloni’s L’ebreo in La Fenice, (1857) and Galieno in Errico Petrella’s Morosina ovvero L'ultimo de' Falieri in Naples (1860).

In the spring of 1860 he created the title role of Luigi Moroni's Amleto at the teatro Apollo in Rome, singing with the aging Filippo Coletti as Cladio.

The tessitura for the role of Gabriele Adorno he created was so low that Verdi later authorised transpositions up for the tenor Emilio Pancani in 1869[4] and adapted the part himself for Francesco Tamagno in 1881.