The club is the most important in the city having represented Trujillo in the first division of Peruvian football in multiple occasions since the late 1960s.

The club has a long rivalry with Alfonso Ugarte de Chiclin, and matches between the two teams are known as ''El Clásico Trujillano''.

Carlos A. Mannucci was founded as a multi-sport club on November 16, 1959 at the request of a group of female volleyball players that had until then been sponsored by Trujillo's Victor Lazarte Hospital.

[3] The club first competed in local volleyball and basketball competitions with funding from the Carlos A. Mannucci Company.

Out of the four provincial teams, Mannucci finished last in ninth place and was thus relegated back to the Copa Perú.

Curiously, that game was played at Alianza Lima's rivals' stadium, Estadio Teodoro Lolo Fernández.

Mannucci, with Paraguayan Miguel Ortega as coach defeated Melgar by 2–0 to win the 1969 Copa Perú, with goals from Jorge García and Alejandro Zevallos.

Cienciano managed a scoreless draw against Unión Minas which gave it an extra point over the Trujillo-side which earlier that day defeated Melgar, with two goals by Fabían Arias, but wasn't able to avoid relegation.

That year Mannucci overcame the Regional stage by defeating Ramón Castilla, Deportivo Municipal de San Ignacio, and Unión Tarapoto in group B.

It defeated Unión Deportiva Chulucanas in the Round of 16 but was unable to overcome Willy Serrato in the quarterfinals.

Yet because of the team's great performance that season, it was invited to participate in the Second Division tournament for the first time in its history.

The stadium is part of the Mansiche Sports Complex and has hosted numerous events, most notably the 2004 Copa América, and 2005 FIFA U-17 World Championship.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.