[1] Adames made his professional debut in July 2015, defeating Jeff Souffrant by unanimous decision after four rounds.

Adames won the vacant WBA Fedecaribe welterweight title in his seventh bout, beating Kelly Figueroa.

[citation needed] On 30 November 2019, Adames faced Patrick Teixeira for the vacant WBO interim super welterweight title.

[5] On the 8th of October, 2022, at the Dignity Health Sports Park, Carson, California, U.S., Adames went up against Uruguayan boxer Juan Macias "Juanito" Montiel for the WBC (Interim) Middleweight title.

[7] Adames was scheduled to defend his WBC middleweight title against Terrell Gausha at MGM Grand Garden Arena in Las Vegas on June 15, 2024.