The Senate of Argentina declared the Museum a place of social, cultural and educational interest in 2015, as a recognition of its institutional work.

Fossil remains include mesozoic tetrapods, such as the original skull of Abelisaurus comahuensis, a meat-eating dinosaur that lived in Patagonia during the Cretaceous.

[2][3] Remains of other taxa of theropods are exhibited, including Buitreraptor gonzalezorum, Alnashetri cerropoliciensis, Bonapartenykus ultimus and Quilmesaurus curriei, as well as ornithopods such as Willinakaqe salitralensis.

This collection consists of lithic material (mortars, pestles, grinders, bolas, arrow heads, knives, racloirs, et cetera) and numerous pieces of pottery.

The Carlos Ameghino Museum includes a laboratory for cutting thin slices of contemporary and fossil bones for histological studies.