A native of Barquisimeto, Venezuela, Asuaje attended St. Thomas Aquinas High School and played college baseball at Nova Southeastern University in Broward County, Florida.

[3] Asuaje was selected by the Boston Red Sox in the 11th round of the 2013 MLB draft, and came to terms on a contract calling for a reported bonus of $100,000.

[1] Asuaje debuted professionally with the Low–A Lowell Spinners in their 2013 season, starting his career as a shortstop, but eventually moved full-time to third base where his skills profiled best.

With 11 home runs, 10 triples and 24 doubles, he topped the South Atlantic League with a .542 slugging percentage and made the All-Star team before joining the High–A Salem Red Sox on July 14.

He showed a progressive approach with an 11-game hitting streak from August 14–25, 2014, to finish the year with a .323/.398/.516 line, four home runs and 28 RBI.

[8] The Padres acquired Asuaje along with Javier Guerra, Manuel Margot and Logan Allen in November 2015, in the same transaction that sent Craig Kimbrel to the Boston Red Sox.

[9] Asuaje opened 2016 with the Triple-A El Paso Chihuahuas of the Pacific Coast League as the regular second-baseman.

[10] The Padres promoted Asuaje to the major leagues on September 21, 2016, once the Triple-A team ended their playoff run.

After a brief call-up in May, he joined the Padres again on June 23 to become the primary second-baseman after Yangervis Solarte went to the disabled list with an oblique strain.