His expertise was borne out of his experiences as a shareholder, CEO, and a board member of over a dozen corporations across multi-industries such as power, agriculture, mining, banking, hospitality, real estate, and investment.

His grandfather Carlos Domínguez Sr. was a pre-World War II head of the Bank of the Philippine Islands (BPI) in Mindanao.

He also pursued post-graduate studies in California where he completed the Executive Program from Stanford University's Graduate School of Business in 1982.

[5] From 1969 thru 1982, Dominguez managed agriculture-related enterprises ranging from agricultural machinery distribution and 5,000 hectares of farmland producing bananas for export, as well as coconuts, cacao, rice, and cattle.

He assumed the leadership of the Ministry of Natural Resources in 1986 and the Department of Agriculturein 1987 while also serving as Director of the government-owned Land Bank of the Philippines.

[5] In his long business career after his first stint in government, Dominguez served on the boards of RCBC Capital Corp. House of Investments, Shangri-la Plaza Corp., Northern Mindanao Power Corp., Easycall Communications Philippines, Lafayette Philippines, Transnational Diversified Group, Central Azucarera Don Pedro, Roxas Holdings, and United Paragon Mining Corp. From 2001 to 2003, he served as Director of Meralco.

[8] President Duterte signed into law the TRAIN Act on December 19, 2017, which reduced the personal income taxes for 99 percent of taxpayers in the country, giving them much-needed relief after 20 years of non-adjustment.

It was also under his leadership that the BIR was able to collect its largest tax settlement from a single taxpayer in Philippine history amounting to PHP 30 billion or USD 600 million.

Dominguez also succeeded in placing the Philippines in a more stable fiscal position by combating corruption and modernizing the country's tax collections and payments.

Dominguez was conferred by the President of the Philippines with the Order of Lakandula with the Rank of Grand Cross (Bayani) for his exemplary service to the nation.