Carlos Holmes Trujillo García (23 September 1951 – 26 January 2021) was a Colombian dynasty politician, diplomat, scholar, and attorney who served as minister of defense, foreign affairs, interior, and education.

He was the elder son of powerful Liberal Party mogul, congressman, diplomat and attorney Carlos Holmes Trujillo Sr. and Genoveva García.

[2] After finishing his education in Tokyo, Trujillo returned to Colombia in 1983 and was appointed Cali's Finance Secretary by Mayor Julio Riascos (Conservative Party).

[4] While formally running the country's third largest city, Trujillo expanded his power by founding the Colombian Federation of Municipalities (FCM) and becoming its chairman.

[citation needed] The president appointed Trujillo as ambassador to the OAS in the middle of Proceso 8000, a criminal investigation into Cali Cartel Funding of Samper's presidential campaign the year before.

In 2006, Uribe appointed Trujillo ambassador to the European Union, a post he would hold until a year after the 2010 election of President Juan Manuel Santos.

Trujillo became Zuluaga's running-mate in opposition to Santos in the 2014 elections, but failed to defeat the incumbent president, who by then was in the middle of peace talks with the FARC that were fiercely opposed by the "Uribistas."