Carlos Manuel Santiago (March 2, 1926 – December 21, 2008) was an infielder in Puerto Rico and Negro league baseball, and a long-time scout and general manager.

He was scouted by Negro league veteran John Beckwith who signed him to play for the Atlanta Black Crackers.

Midway through the 1945 season, Santiago left the Black Crackers and signed with the New York Cubans of the Negro National League.

This was the same season that Jackie Robinson joined the Dodgers; Santiago was the first Afro-Caribbean Puerto Rican to break the color line in "organized" baseball.

In 1951 Bill Veeck and Lou Boudreau invited Santiago to Cleveland's spring training camp.