Carlos Medina Plascencia (born 14 August 1955 in León, Guanajuato) is a Mexican politician affiliated with the conservative National Action Party (PAN).
He is a former mayor of León, senator and interim governor of Guanajuato (1991 – 1995).
He is the son of Carlos Medina Torres and María del Carmen Plascencia Fonseca.
He graduated with a bachelor's degree in chemical engineering and a master's degree in business administration from the Monterrey Institute of Technology and Higher Studies (ITESM), where he worked as a professor from 1980 to 1981.
In 1985, he joined the National Action Party and a year later was elected city councilor of León.