[10] Cuse is known for his groundbreaking cross-genre storytelling, pioneering work in interactive media, collaborative achievements, and mentorship of many screenwriters who went on to become showrunners of television series.

The film, reuniting Cuse and Condal with San Andreas director Brad Peyton, producer Beau Flynn, and star Dwayne Johnson, began production in early April 2017 for New Line/Warner Bros.

[17][18] Because of his involvement with Indiana Jones and the Last Crusade, an executive at Fox, Robert Greenblatt, asked Cuse and Boam if they would be interested in doing a television version of the old movie serials.

Cuse said yes and wrote The Adventures of Brisco County, Jr., about a Harvard-educated bounty hunter who wants to avenge the death of his father, the most famous lawman in the Old West.

Boam went back to making features, leaving Cuse to write and serve as sole showrunner of the critically acclaimed series.

Cuse adapted the world of Hong Kong cinema to American television in a story about a Shanghai cop who comes to the LAPD on an exchange program.

To reduce his workload to a manageable level, Cuse stepped back from the second season of Martial Law to focus exclusively on Nash Bridges.

Cuse's interest in the material and a conviction that he could turn Lost into a long-running series led him to opt out of a lucrative studio deal elsewhere to take the job as showrunner.

[23] While ostensibly about a group of plane crash survivors trying to return to civilization, Cuse and Lindelof said the show thematically was about people who are metaphorically lost in their lives and seeking to find themselves again.

[32] The Writers Guild of America, in citing Lost as one of the 101 Best Written TV Series, described the show as "A pastiche of genres...co-mingled to intoxicating effect...[pushing] the idea of how much narrative ground you could cover in television...The ingenuous structure worked both as drama and metaphor.

"[33] As Lost marked its 20th anniversary in September of 2024, numerous retrospectives highlighted the show's profound impact on television and its enduring success, The Wrap notes the innovative storytelling, the blend of high-concept mysteries and deep character development.

[36] Cuse was the creator, writer, showrunner, and executive producer with Kerry Ehrin of the A&E series Bates Motel, which premiered on March 18, 2013, on the A&E Network.

The first season received critical praise, with Vera Farmiga (Norma Bates) being nominated for the Primetime Emmy Award for Outstanding Lead Actress in a Drama Series in 2013.

[45][46] Cuse was showrunner, executive producer, developer, and writer of The Strain, an FX drama series based on the vampire novel trilogy by co-authors Guillermo del Toro and Chuck Hogan.

Cuse and del Toro decided to end the series after the fourth season of their own accord, feeling it was the right time to bring the story to a close on their own terms.

In the final season, the talented cast, the gorgeous effects, and the singular cinematographic aesthetic are matched [by] bold narrative moves and satisfying character beats.

"[49] Cuse was showrunner, co-developer, writer, and executive producer of The Returned, based on the popular and International Emmy Award-winning French suspense series Les Revenants, adapted by Fabrice Gobert and inspired by the feature film, They Came Back, directed by Robin Campillo.

The Returned was co-produced by A+E Studios and FremantleMedia North America in association with Haut et Court TV SAS, the producer of the French series.

Cuse and Ryan Condal served as creators, showrunners, and executive producers of Colony for the USA Network, a co-production between Legendary Television and Universal Cable Prods.

Colony "is a family drama/thriller about life in Los Angeles after a mysterious 'foreign' occupation, and the efforts by the proxy government to crush the growing resistance movement."

[59] The series stars John Krasinski as Ryan, "an up-and-coming CIA analyst as he uncovers a pattern in terrorist communication that launches him into the center of a dangerous gambit with a new breed of terrorism that threatens destruction on a global scale".

[65] Cuse was showrunner, executive producer, developer, writer and director of Locke & Key, an adaptation of Joe Hill's comic-book series.

[73] On January 19, 2021, Netflix CEO Ted Sarandos announced on a quarterly investor call that Locke & Key was a Top 10 show worldwide for 2020 based on Google search metrics.

It is based on the 2013 book Five Days at Memorial: Life and Death in a Storm-Ravaged Hospital by New York Times journalist Sheri Fink.

Her original reporting for the Times and ProPublica, depicting the difficulties a New Orleans hospital endured after Hurricane Katrina made landfall on the city, led to her being awarded the Pulitzer Prize.

...Every performance (especially Vera Farmiga as Dr Anna Pou, Julie Ann Emery as nurse Diane Robichaux and Raven Dauda as the daughter eventually forced to abandon her dying mother) is quietly brilliant.

"[78] Rachel Syme wrote in The New Yorker, "If you have the stomach to dig into a nightmarish tale of systemic failure and murky medical ethics, you’ll be rewarded with truly masterly performances.

The show examines the lives of the staff of Miami’s busiest Level 1 Trauma Center, who navigate medical emergencies, and it follows young ER doc Danny Simms, who is unexpectedly promoted to Chief Resident amidst the fallout of her own provocative romantic relationship.

Cuse has been nominated for ten Primetime Emmy Awards for his work on Lost and has won twice: first in 2005 for Outstanding Drama Series, then in 2009 for Creative Achievement in Interactive Media.

[90] That same year, Cuse won the Dan Curtis Legacy Award from the Academy of Science Fiction, Fantasy and Horror Films, for lifetime achievement.