María del Carmen Gana López (1800 – 15 April 1880) was a Chilean aristocrat and a First Lady of Chile.

[1] Blanco acted as Interim President of Chile from 9 July 1826 until 9 September 1826, during which Gana served as First Lady.

In spite of her short tenure, Gana used her position as an opportunity to act on her passion for social service.

She arranged for her husband to allow the Congregation of the Good Shepherd, a Catholic religious order, to establish the first orphanage in San Felipe.

[2] During her husband's tenure as a minister to France, their home in Paris became a point of gathering for distinguished Americans and Europeans.