The endowment of the Trust on establishment was $10 million (an unprecedented gift, amounting to around 200-times the annual governmental funding of the four Scottish universities at the time).
Under the terms set down by Andrew Carnegie, one half of the Trust's income is reserved for "the improvement and expansion of the Universities of Scotland" with the other half to go towards "the payment of fees of students of Scottish birth or extraction in respect of courses leading to a degree of a Scottish University".
(Prior to Scottish devolution, the Secretary of State for Scotland held the ex officio post currently occupied by the First Minister.)
The Executive Committee, which manages the Trust itself, consists of five of the nominated Trustees and four of the Principals of the Scottish Universities in rotation.
On behalf of the Royal Society of Edinburgh, the Henry Dryerre Scholarship is for postgraduate study by a graduate of a Scottish university in medical or veterinary physiology.
Such expeditions are to have "a coherent research programme and must be accompanied throughout by a member of staff or someone of equal standing acceptable to the Trust".
The Scheme awards funding for "joint programmes of collaborative research projects from groups within the Scottish Universities".