[1] After graduating from Mayfield High School, Rendon entered Northwestern University as a theater major but opted to pursue political science instead.

Rendon began her legal career as a law clerk to Judge Joel Flaum on the United States Court of Appeals for the Seventh Circuit from 1987 to 1988.

She served in the United States Attorney's Office for the District of Massachusetts as the Organized Crime Drug Enforcement Task Force Chief from 1994 to 1997 and as an Assistant United States Attorney in the Organized Crime Strike Force from 1988 to 1994.

She served as Acting United States Attorney for the Northern District of Ohio since February 2016.

Her nomination was reported by the United States Senate Committee on the Judiciary on June 30, 2016.