[5][6] In 2015, Genco joined the Tufts University School of Medicine as the Arthur E. Spiller Professor in Genetics and chair of the Department of Immunology.

[7] She succeeded Nadine Aubry as provost and senior vice president ad interim of Tufts University on January 1, 2022, and was appointed to those positions on a permanent basis on August 1, 2023.

One specific research area of the lab is how mucosal pathogens work to evade macrophages/monocytes and the innate immune response in general.

Specifically, the lab has uncovered some of the mechanisms by which Fur (ferric uptake regulator), a regulatory protein, affects the virulence of bacteria.

[9] Genco maintains a particular interest in antibiotic resistance and immune response to Neisseria gonorrhoeae, and especially how these differ in male and female human hosts.