She was a daughter of George Montagu, 4th Duke of Manchester, by his wife Elizabeth Dashwood.
The duke and duchess had six children: The duke, prior to his second marriage, had been a lover of the notorious Seymour Fleming, Lady Worsley, who, in February 1782, was the subject of a criminal conversation case for £20,000 (2015: £2,220,000), brought by her husband against Maurice George Bisset.
Lady Worsley retaliated with scandalous revelations, and her doctor, William Osborn, testified that she had suffered from a venereal disease which she had contracted from the Marquess of Graham.
The case was presided by Lord Mansfield (great uncle of George William, 10th Earl of Winchilsea)[5] The duchess was allegedly one of the titled ladies who hissed at Queen Victoria in the royal enclosure at Ascot Racecourse in 1839, following the scandal over the queen's treatment of Lady Flora Hastings.
In the 2009 film The Young Victoria, the duchess is played by Alice Glover.