Caroline Henderson Griffiths (November 26, 1861 – August 13, 1937) was an American diplomat's wife and philanthropist.

After World War I, she organized book and equipment donations for children's libraries in Belgium and France.

[5] In Indianapolis, she supported the Flower Mission Home for Incurables,[6] a hospital she helped establish in 1903.

[10] Griffiths is credited with bringing the first children's libraries and reading rooms in Paris and Brussels.

[12] "In establishing children's libraries and reading rooms in Belgium and France," she explained, "we are only paying a little on a very large debt which America owes to Europe for the delightful hours the children in every generation have received from the great storytellers in Europe.