[1] From 2000 to 2010 she was the vice president and director of John Snow, Inc. (for-profit) and JSI Research and Training Institute, Inc. (non-profit) in the Washington, D.C., area.

[1] At the time of her nomination she was the director at the JSI Research and Training Institute, Inc, a global public health organization, where she oversaw the management of programs in more than 30 countries.

[3] Hessler-Radelet was a board member of the National Peace Corps Association and served on the steering committee for the US Coalition for Child Survival.

[3] During her time as deputy director, she led the roll-out of the Focus In/Train Up initiative, which provides targeted technical training to volunteers to increase their capacity-building abilities.

[1][7] As Peace Corps director, Hessler-Radelet has led an extensive organizational reform effort, most notably to enhance the health and safety of trainees and volunteers (including the development of a sexual assault risk reduction and response program); improve the quality of Peace Corps’ technical training and program support for volunteers; increase the impact and operational efficiency of agency operations; strengthen intercultural competence, diversity and inclusion; enhance the visibility and image of Peace Corps; attracted record numbers of applicants; and expand and strengthen public-private partnerships to increase funding, enhance brand image and strengthen technical programming.

[8] On February 20, 2013, President Barack Obama announced the delegation to attend the inauguration of Ernest Bai Koroma of Sierra Leone.

Hessler-Radelet and her husband, international development economist Steven Radelet, served together as a couple in the Peace Corps and have two grown children.