In his senior year, Edwards led Atascocita with averages of 26.3 points, 5.1 assists and 4.9 rebounds per outing, earning MaxPreps All-America Fourth Team[3] and first-team All-State honors.

[4][5][6] Edwards made an immediate impact as a freshman at Purdue, appearing in all 35 games (21 starts) and averaging 10.3 points as well as 2.6 boards and 1.8 assists a contest.

On September 25, 2018, Edwards was named the Blue Ribbon Yearbook Pre-Season College Basketball National Player of the Year.

[13] On January 31, 2019, Edwards made a then school-record eight three-point shots to go with 38 points in a 99–90 overtime win versus Penn State.

On March 23, during the NCAA Tournament, Edwards scored a career-high 42 points on just 21 shots in a blowout 87–61 win over the defending champions and #6 seed Villanova.

He is also all-time 3rd place in most 25-point games in a row in the NCAA tournament, tying current NBA player Stephen Curry with 5.

[16] Following Purdue's loss in the 2019 NCAA men's basketball tournament, Edwards announced his intention to forgo his final season of collegiate eligibility and declare for the 2019 NBA draft, where he was projected to be an early second-round selection.

[18][19] Edwards played for the Celtics during the 2019 NBA Summer League season and averaged a team high 19.4 points, 3.8 rebounds, and 1.4 assists in 23.4 minutes over five games.

[20] After clinching the number one seed in the tournament, the Celtics were eliminated in the first round by the eventual champions, the Memphis Grizzlies, despite a 25 point, 8 rebound effort by Edwards.

[34] On July 21, 2023, Edwards signed a one-year contract with Bayern Munich to play in EuroLeague for a second consecutive season.

[36] Edwards was named to the roster of the US national team for the 2017 FIBA Under-19 Basketball World Cup in Egypt,[37] where they captured a bronze medal.