The studio has produced dozens of shows, including Dexter's Laboratory, The Powerpuff Girls (and its film adaptation), Johnny Bravo, Time Squad, Samurai Jack, The Grim Adventures of Billy & Mandy, Foster's Home for Imaginary Friends, Camp Lazlo, Ben 10, Chowder, The Marvelous Misadventures of Flapjack, Adventure Time, Generator Rex, Regular Show, Steven Universe, Clarence, We Bare Bears, OK K.O.!

This was due to the need for Cartoon Network Studios to become an independent entity dedicated to creating original series, while Warner Bros.

Hanna-Barbera became the premier studio for small-screen animated programs, launching a dominant series of Saturday-morning fare, including Scooby-Doo, The Flintstones, The Jetsons, and more.

[5] Turner founded several cable channels and also acquired vast film libraries, and in 1991 his company signed a joint deal to buy Hanna-Barbera.

Hanna-Barbera had been located on Cahuenga Boulevard in Los Angeles since 1963, and housed the studio, its archives, and its extensive animation art collection.

[15] The network took counsel from its top cartoonists, Genndy Tartakovsky and Craig McCracken, on the site of its new studio, as well as design proposals for its offices.

[17] The building's official opening came on August 24, 2000; former DiC and Nickelodeon employees Brian A. Miller and Jennifer Pelphrey were hired to manage the studio.

[18] Mike Lazzo, then head of programming and development,[19] designed a pirate flag, with a skull bearing the channel logo in its teeth, that flew over the building for several weeks before local police threatened action over its lack of permit.

"[22] In 2002, the studio produced two television pilots for Cartoon Network's late night programming block Adult Swim: Welcome to Eltingville and The Groovenians, neither of which were picked as full series.

In 2006, CNS collaborated with sister studio Williams Street for the first time for Korgoth of Barbaria, a television pilot made for Adult Swim, which was also not green-lit as a series.

Former New Line Television producer Mark Costa was hired to oversee the projects and CNS' live-action production company Alive and Kicking, Inc..

On April 5, 2010, Adventure Time premiered on Cartoon Network; the same series began life as a short featured on Nicktoons' Random!

[35] In 2017, after plans as old as 2002[36] for a film didn't work,[37] Samurai Jack was revived for a fifth and final season, which the studio returned to produce for Adult Swim,[38] to critical acclaim,[39][40] concluding the series after its cancellation from Cartoon Network in 2004.

Also this year, it was announced that CNS, in collaboration with Studio T, would produce the adult animated series Close Enough for TBS, created by Regular Show creator J. G.

[41] In 2019, after handling a few episodes of Harvey Birdman, Attorney at Law, the second season of Black Dynamite, the above-mentioned fifth season of Samurai Jack and producing the above-mentioned television pilots Welcome to Eltingville, The Groovenians and Korgoth of Barbaria, CNS produced its first full program for Adult Swim: Primal, an adult animated series from Genndy Tartakovsky.

[42] CNS also began to produce content for parent company WarnerMedia's upcoming streaming service HBO Max, including Adventure Time: Distant Lands.

Global Kids, Young Adults and Classics division was broken up as part of a restructuring by new owner Warner Bros.

While unconfirmed, Amid Amidi of Cartoon Brew reported its production teams would move to the Second Century Development, a pair of buildings with over 800,000 square feet of office space,[51] just adjacent to the Warner Bros.