It was formerly a political party, born as a network of far-right social centres arising from the occupation of a state-owned building by squatters in the neighborhood of Esquilino in Rome on 26 December 2003.

[24] In order to participate in the 2019 European Parliament election in Italy, an electoral joint list was formed by CasaPound together with United Right.

[30] The name, inspired by the poet Ezra Pound, refers to his Cantos against usury, criticisms of the economic positions of both capitalism and Marxism, and his cooperation with the Italian Social Republic.

[36] In 2017, the establishment of CasaPound expressed support for same-sex civil unions,[37] advance directive and improvement of the welfare state.

[40] Some activists of the movement expressed antisemitic and xenophobic rhetoric online,[41] but CasaPound both refuses and expels members who support these ideas.

[49] In 2018, Di Stefano defended Israeli Prime Minister Benjamin Netanyahu's policies regarding repatriation of illegal immigrants to Africa as "undoubtedly excellent", and criticised humanitarian organisations and the United Nations for intervening to prevent them.

[51][52] Di Stefano has expressed support for U.S. President Donald Trump, but requested that he close U.S. military bases in Italy.

[53] Although leader Di Stefano has maintained outspoken support for Russian President Vladimir Putin, CasaPound has always taken a pro-Ukraine stance, being closely linked with the nationalist organization Right Sector, with members fighting among the ranks of the Azov Battalion and Misanthropic Division.

[54] This positions the organization as opposed to its neo-fascist rival New Force, which although a former Italian ally of the Ukrainian party Svoboda, it has, since 2014, taken a pro-Russian stance in the conflict and sent fighters to Donbas.

[55] According to the Italian edition of the HuffPost, members of CasaPound went to fight in Ukraine, among them Francesco Saverio Fontana, who enlisted in the Azov Battalion.

[58][59] From the period of activity of the first social centre then were organized and cultural meetings with several guests, including writer Nicolai Lilin,[60] the LGBT deputy Paola Concia,[61] an ex-Red Brigades Valerio Morucci,[62] and the Chinese community.

[73] Over the years the leaders of CasaPound Italy have been invited to explain its “political model” in many of the major European capitals (Paris, Madrid, London, Lisbon, Brussels, Warsaw)[74] and the organization has been the subject of some reports by foreign media.