Casale Litta is a comune (municipality) in the Province of Varese in the Italian region Lombardy, located about 45 kilometres (28 mi) northwest of Milan and about 10 kilometres (6 mi) southwest of Varese.

Casale Litta borders the following municipalities: Bodio Lomnago, Crosio della Valle, Daverio, Inarzo, Mornago, Varano Borghi, Vergiate.

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