Casas Grandes Municipality is located in the northern Mexican state of Chihuahua.

The site of Casas Grandes, alternatively known as Paquimé, is one of the most significant pre-Columbian cultural and archaeological sites in the region of northwestern Mexico and the southwestern United States known in some archaeological contexts as the Oasisamerica culture area.

(Pueblo de) Casas Grandes, the municipal capital and its most populous localidad (locality or settlement), is approximately 359 kilometres (223 mi) to the northwest of the state's capital, the city of Chihuahua.

On its western flank Casas Grandes adjoins municipalities within the state of Sonora.

[2] Other than the town of Casas Grandes, the municipality had 296 localities, the largest of which (with 2010 populations in parentheses) were: Juan Mata Ortíz (Pearson) (1,182) and Colonia Juárez (1,035), classified as rural.