The Cascade and Columbia River Railroad (reporting mark CSCD) is a short line railroad that interchanges with BNSF Railway in Wenatchee, Washington, and runs north to Oroville.

The line from Wenatchee to Oroville was built in 1914 by the Great Northern Railway[2] to link the main line at Wenatchee to a line Great Northern had built under the Vancouver, Victoria and Eastern Railway (VV&E) charter in British Columbia (Canada), and the Washington and Great Northern Railway (W&GN) charter for Washington (US).

[3][4] The former Burlington Northern W-O Branch was purchased by the RailAmerica Corporation in September 1996.

[5] Genesee & Wyoming later acquired the railroad in late 2012.

Commodities hauled on the railroad consist mainly of timber products, as well as limestone.