Cascilla is an unincorporated rural hamlet located in Tallahatchie County, Mississippi.

Cascilla is approximately 7 miles (11 km) southeast of Paynes and approximately 6 miles (9.7 km) south of Charleston, at the intersection of Cascilla Road and Smith Road.

There is a general store and post office along with several homes in the community.

Jamie L. Whitten, the second-longest serving U.S. Representative and the fifth-longest serving member of the U.S. Congress, was born in Cascilla.

This Tallahatchie County, Mississippi state location article is a stub.