Murphreesboro (also New Hope) is a ghost town in Tallahatchie County, Mississippi, United States.

Murphreesboro was located approximately 10 mi (16 km) southeast of Charleston.

Ascalmore Creek flowed through the settlement.

[2][3][4] Blues guitarist Hayes McMullen was born in Murphreesboro in 1902.

This United States ghost town-related article is a stub.