Between 2014 and 2021, he played in Major League Baseball (MLB) for the Pittsburgh Pirates, Tampa Bay Rays, Los Angeles Dodgers, Chicago Cubs, and Seattle Mariners.

[2] The Pirates selected Sadler in the 25th round of the 2010 Major League Baseball draft,[3] He made his professional debut with the Low-A State College Spikes.

In 2013, Sadler split the year between the Double-A Altoona Curve and the Triple-A Indianapolis Indians, posting an 11–7 record and 3.37 ERA between the two teams.

He was recalled by the Pirates on April 27,[5] and made his major league debut against the Toronto Blue Jays on May 2.

[9] In 2017, Sadler split the season between Bradenton, Altoona, and Indianapolis, registering a 4.00 ERA with 66 strikeouts in 78.2 innings of work.

[16] On July 3, 2019, the Rays traded Sadler to the Los Angeles Dodgers in exchange for Nathan Witt.

Overall, he appeared in 24 games for the Dodgers (including making one start) and was 4–0 with a 2.33 ERA while striking out 20 batters in 27 innings.

[19] On January 17, 2020, the Chicago Cubs acquired Sadler from the Dodgers in exchange for infielder Clayton Daniel.

[25] On November 9, Sadler was removed from the 40-man roster and sent outright to the Triple–A Tacoma Rainiers; he subsequently elected free agency the same day.