The 331st was converted to a Very Heavy (B-29) group in July 1944 and began training for deployment to the Twentieth Air Force in the Pacific.

Casper AAF became part of the Air Transport Command as a transit station for WASP pilots ferrying combat aircraft across the United States.

SkyWest previously served Casper with nonstops to Salt Lake City using Canadair CRJ-200 regional jets.

[10] By 1970, Frontier began replacing their Convair 580 turboprop flights with Boeing 737-200 jet service primarily to its Denver (DEN) hub as well as to Billings, Bozeman, and Missoula, Montana and Jackson and Riverton, Wyoming.

[11] Continental Airlines began flights in 1980 when this air carrier was operating a hub at Denver and was serving Casper with Boeing 727-200 and Douglas DC-9-10 jetliners.

Prior to becoming a Continental Express air carrier in 1987, Rocky Mountain Airways served Casper from 1983 through 1985 as an independent airline with de Havilland Canada DHC-7 Dash 7 turboprops.

[14] In 1987, United mainline jets were replaced with United Express service flown by Aspen Airways (1987–1990) with Convair 580 turboprops and British Aerospace BAe 146-100 jet aircraft, then by Mesa Airlines (1990–1998) with Beechcraft 1900C, de Havilland Canada DHC-8 Dash 8 and Embraer EMB-120 Brasilia aircraft.

Air Wisconsin then provided United Express service (1998–2002) with Dornier 328 propjets followed by Great Lakes Airlines (2001–2003) using Beechcraft 1900D aircraft.

The Wyoming Department of Environmental Quality's main concern is chemical contamination in the area of a former landfill and sewage treatment plant.

[18] On November 13, 1944, a USAF Douglas C-47 struck terrain and crashed shortly after takeoff 3.1 miles NW of then Casper AAF, Wyoming.

[2] In the year ending December 31, 2022, the airport had 43,126 aircraft operations, average 118 per day: 71% general aviation, 4% scheduled airline, 23% air taxi and 2% military.

FedEx Feeder operator Corporate Air flies a fleet of Cessna 208's to serve freight throughout Wyoming, Nebraska, and Colorado.

In the 2011 comedy film Bridesmaids, an airplane makes an emergency landing at the airport to deplane a rowdy flier and her group of friends.