Hack/Slash has included crossovers with other franchises with Cassie and Vlad encountering Evil Ernie,[4] Chucky,[5] a horde of treehuggers[6] and Herbert West from the cult-classic Re-Animator film series.

Her father left soon after she was born, leaving Cassie with her overbearing, eccentric mother who worked as a cook at a nearby high school.

Two years later, children began disappearing once more, signalling the return of her mother, reborn as a vengeful "slasher" trying to continue its murderous spree.

Cassie befriended the Meatman, a misshapen man named Vlad, and together they hunted down the actual murderer, a local minister/assassin with Mafia connections.

[9] While investigating the situation, Cassie becomes extremely drunk (when a boy drugged her ice tea with pure vodka) and having lost her inhibitions, flirts with a stranger and kisses a random girl.

Despite being less than sober, she continues her investigation and encounters a crazed Catholic schoolgirl, Laura Lochs, who controls an undead preacher named Father Wrath.

After a prolonged fight, Vlad kills Father Wrath and Cassie sets Laura on fire and leaves her for dead.

[10] When Evil Ernie awakens in the Hack/Slash universe he begins a killing spree, murdering six women near a strip club in New Jersey.

A tip from Lisa, who has been staying in contact, leads Cassie and Vlad to investigating the circumstances behind nine children dying in their sleep.

[11] Their contact, Jason, concludes that the person responsible is Ashley, a Freddy Krueger-esque slasher who can kill people in their dreams.

Soon afterward, Cassie teams-up with a possessed doll, Chucky, in order to confront Laura Lochs who has returned and stolen Vlad's body using a voodoo amulet.

While caged, Cassie talks to a local dog named Pooch, who tells her that the singer, Six Sixx, has made a deal with a demon.

Some time later, Cassie is forced to sell her mother's wedding ring in order to pay for better accommodation while Vlad recovers from a respiratory infection.

After Vlad is attacked, Cassie begins questioning the local students and discovers that a number of them are lesbians who are involved in a cult surrounding the mythology of Elizabeth Bathory.

Cassie, Vlad and the government team are led to the cult's underground base where they are attacked by Ms. America, who has been stealing the blood and skin of students in an attempt to regain her original beauty.

After Nathan exacts his revenge (he's fatally wounded in the process) Cassie, still confused by her feelings for Georgia, asks him how he knew that he was in love.

Afterwards, Cassie takes a break from searching for her father to investigate a series of killings in Hitchfield, Georgia and encounter a horde of treehuggers and their puppet master, Eddie.

Cassie confides in Georgia that she can't go on killing slashers and wants to live a normal life, thoughts which alienate Vlad.

While being transported to a detention center Cassie is broken out by the Society of the Black Lamp, who attempt to ritualistically murder her as punishment for destroying slashers.