Castel di Casio (Medial Mountain Bolognese: Castèl or Castèl d Chèsi) is a comune (municipality) of the Metropolitan City of Bologna in the Italian region Emilia-Romagna, about 60 kilometres (37 mi) southwest of Bologna.

Castel di Casio borders the following municipalities: Camugnano, Gaggio Montano, Grizzana Morandi, Alto Reno Terme, Sambuca Pistoiese.

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