It runs from the junction of Lothbury, Old Jewry and Coleman Street at its eastern end, to St. Martin's Le Grand in the west.

[2] The nearest London Underground stations are St Paul's, which can be reached via St. Martin's Le Grand to the south from its western end, and Bank, via Lothbury and Princes Street, a short distance to the south from its eastern end.

A famous coaching inn, The Swan With Two Necks, once stood on the former Lad Lane, at the junction of Gresham Street with Milk Street – one of the historic side-streets which leads off to the south towards Cheapside.

There is a memorial garden on the site of St. Mary Aldermanbury, a Christopher Wren church, that, following damage in the Blitz, was dismantled and rebuilt in Fulton, Missouri.

Gresham Street is home to the Lloyds Banking Group's headquarters and also to Investec, Alliance Trust and Rensburg Sheppards.