Born in the Netherlands, Biddle immigrated to Long Island, New York at age 12, accompanied by her sister Mary Baart Snelling.

She spent the next several years painting, studying at the Académie de la Grande Chaumière in Paris and meeting artists including Henri Matisse, Raoul Dufy, and Pablo Picasso.

[2] After returning to Washington, D.C. in the early 1950s, Biddle began to work as an educator, teaching at public schools, the National Gallery of Art, and taking private students.

Over the last few decades of her life, Biddle was featured in several solo and group exhibitions and worked, along with her husband, as an active proponent for women artists and art education.

[4] Biddle's work is noted for its emphasis on light, shadow and color, and the influence of Dutch masters including Rembrandt and Van Gogh.