Catharina Lysholm (née Meincke; 1744 - 9 December 1815), was a Norwegian businesswoman and ship-owner.

Her father was co-owner of the copper works at Løkken and Røros, organized a West Indies company and operated a tobacco factory.

Upon the death of her spouse in 1772, she took over his business interests in partnership with Hans Carl Knudtzon who had moved to Trondheim from Bredstedt in North Frisia.

[6] She managed the perhaps largest ship company in Trondheim from 1772-1779 operating under the name Fru Agentinde Lysholm & Co. By 1779, she was one of the co-founders and owners of the city's shipyard at which time she pulled herself out of the company and Knudtzon became the sole owner.

She participated in philanthropy, and erected several buildings, among them the manor at Havstein (1772), which became a center of the local upper class society.