The 19th century entered the Neoclassical style, leaving us, among other works, its maximum example, the new Major Church, today the Cathedral Basilica corresponding to the years 1809-1836, and whose author was the Spanish, Franciscan friar and architect by profession Manuel de Sanahuja,[5] introducer in Potosí of the Neoclassical style, who simultaneously to the Cathedral did other works in both religious and civil architecture.

The current Cathedral Basilica, which occupies the same space as its predecessor, is the work of the architect Friar Manuel de Sanahuja, who began it on Tuesday, September 6, 1808.

It was completed in 1836,[5] consecrating it solemnly on April 4, 1838, in the Presidency of Marshal Andrés de Santa Cruz, who sponsored the ceremony.

Its finish, in addition to being expensive, lasted until the end of the century; Well, in 1597 the carpenter Pedro Gutiérrez, in charge of the high choir, sent his colleague Alonzo de la Plaza to run with the work.

In 1628, master Diego Sayago was commissioned to build a brick portal in the chapel of mercy, which was part of the church.