Cloud area, as of September 2022, Cathedral High School enrolls approximately 750 students grades 6–12.

In 1947, the school made another addition to its campus by purchasing the "North Building" from adjacent Holy Angels church.

Finally, the "South Building" was completed in 1958; shortly thereafter, Cathedral reached its peak enrollment of 1,621 students in 1964.

All of the buildings are connected by tunnels; in the cold Minnesota winter, the administration does not allow students to pass between classes outdoors.

In January 2009, Cathedral High School announced it would tear down the 119-year-old "Zardetti House", built for St.

In January 2014, Anne Schleper, a Cathedral graduate, represented Team USA in women's hockey at the Olympics.

Other special programs that CHS offers include Campus Ministry, Link Crew, mission and language trips, and Student Ambassadors.

Cathedral's home baseball stadiums, Dick Putz Field and Joe Faber Field, located in Saint Cloud, Minnesota, are the sites of the Minnesota Class AA State High School Baseball Tournament, held in June.