Seidenbusch was born on October 13, 1830, in Munich and received his early education there before entering the diocesan seminary in Freising, where he pursued classical and philosophical studies.

[1] Volunteering for missionary work in the United States, he traveled with fellow Bavarian Francis Xavier Krautbauer and arrived in October 1850.

[6] His election was confirmed by Pope Pius IX on March 15, 1867, and he was formally inducted into office on the following May 30 by Bishop George Aloysius Carrell.

[7] Seidenbusch was appointed the first Vicar Apostolic of Northern Minnesota (later the Diocese of Saint Cloud) by Pope Pius IX on February 12, 1875.

[8] Due to ill health, Seidenbusch submitted his resignation on October 19, 1888, and it was accepted by Pope Leo XIII on November 15.