[3] It is the seat of the Greek-Melkite Archeparchy of Damascus (Latin: Archieparchia Damascena Graecorum Melkitarum) dependent on the Melkite Catholic Patriarchate of Antioch, which includes about 150,000 baptized adherents and twenty parishes with fifty priests.

Its faithful, assigned from the 18th century to the Holy See in Rome, employ the Arabic language and the Byzantine rite.

The Archbishop Vicar (or Eparca) starting in 2006 was Youssef Absi, former Superior General of the Society of Missionaries of St. Paul.

[4] The cathedral is dedicated to the Dormition of the Virgin, the Eastern Christian "counterpart" to the Latin Church doctrine of the assumption of Mary.

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