It is the co-cathedral church of the Melkite Greek Catholic Eparchy of Newton, which encompasses the entire United States.

Saint Anne Cathedral was founded in 1909 when Father Gerasimos Sawaya, the first Melkite missionary priest, traversed the west coast visiting and ministering to the Melkites in the Western United States.

On May 20, 2015, Pope Francis named Saint Anne Melkite Greek Catholic Church in Los Angeles, California, as Co-Cathedral of the Melkite Greek Catholic Eparchy of Newton.

[1] In 1976, the Melkite Greek Catholic Church in the United States was elevated from the status of an Exarchate to that of an Eparchy.

On May 8, 1977, at a Patriarchal Liturgy served at the cathedral, the Melkite Greek Catholic Eparchy of Newton was canonically erected with Archbishop Joseph Tawil as Eparch.