The congregation began in 1843 when a small group of Irish Catholic families in the area met for Mass in rented space.

In 1860, parishioner Lawrence Stockton donated a plot of land on Columbia Street to the Reverend Edmund Kilroy for construction of a church, rectory, and school.

The Reverend George Hamilton replaced Father Kilroy as pastor and oversaw completion of construction.

The cathedral has undergone a number of changes including an interior redecoration and addition of a social hall in 2001.

[4] Media related to Cathedral of Saint Mary of the Immaculate Conception (Lafayette, Indiana) at Wikimedia Commons