The enrollment is mostly drawn from local north side suburban municipalities such as Carmel, Fishers, Noblesville, Westfield, and Zionsville.

Founded in 2004, St. Theodore Guerin High School was named after the foundress of the Sisters of Providence, Saint Mother Théodore Guérin.

[4] In the Fall of 2006, St. Theodore Guerin became the first Catholic high school in Greater Indianapolis to become a candidate to offer the International Baccalaureate Diploma Program.

The school is located on seventy-two acres, one mile north of 146th street and Gray road, in the heart of Hamilton County.

The chapel contains twelve stained glass windows depicting St. Junípero Serra, St. Elizabeth Seton, St. Martin de Porres, St. Katharine Drexel, Juliette Toussaint, Pierre Toussaint, St. Juan Diego, St. John Neumann, St. Kateri Tekakwitha, St. Frances Xavier Cabrini, St. Isaac Jogues, and St. Théodore Guérin.

Daily Mass, Eucharistic adoration, and the Sacrament of Reconciliation are offered in the chapel for students, faculty, and staff.

The Grotto is used by its visitors as a sacred space for prayer, reflection and is the location of the school's annual May Crowning ceremony.