[citation needed] This description still applies today, as during the redecorating of the interior after the hurricane of 1989, the colors and applications first used in 1815 were employed as much as current means allowed.

The building was in continuous use during the Civil War, harboring congregations from those churches nearer the strongholds of the Union forces, whose cannons bombarded the city constantly.

Later, the present building was designated the cathedral church for the Diocese of South Carolina, with the leadership of the Rev Dr B Madison Currin.

The stained-glass windows in the apse of the sanctuary were installed in the fall of 1991 and, consistent with the post-hurricane restoration, are in the style of Sir Christopher Wren, the 17th century architect of St. Paul's Cathedral, London.

They were designed and constructed by Willett Studios of Philadelphia and portray, on the left and right, the patron saints of the cathedral (St. Luke and St. Paul) with the center window depicting the crucified Christ, together with St. Mary and St. John.