Her maternal grandfather was Robert Weston, Lord Chancellor of Ireland, and her grandmother was his first wife Alice Jenyngs.

Her dowry of £1,000 allowed Boyle to purchase the estates of Sir Walter Raleigh in east Cork.

He oversaw the household accounts, purchased and chose his wife's clothes, did not allow her to borrow money, and did not seek her opinion on the education or marriages of their children.

Boyle died on 16 February 1630 in Cork House, Dublin, and was buried with her father and grandfather in St Patrick's cathedral.

A book of elegies was printed in her honour, composed by the fellows of Trinity College Dublin titled Musarum Lachrymae.